Tag: KrioRus

KrioRus cryopreserves 12th patient

On May 16, 2010 the only non-US cryonics provider KrioRus announced the cryopreservation of its 12th patient. The patient was pronounced legally dead on May 5 in Kiev and cryoprotectant perfusion was completed on May 7 after initial cooldown and ground transport to Moscow. A more extensive report is available here.

It is encouraging to see more cryonics activity outside of the United States. The statistics of Alcor, Cryonics Institute and KrioRus indicate that there are currently more than 200 cryonics patients in the world and that more than 1,300 people have made cryonics arrangements.

The 2009-1 issue of Cryonics has a two page feature on KrioRus.

Teens & twenties cryonicist event 2010

teens_twenties_2010

This past weekend (Friday, January 8, 2010 to Sunday, January 10, 2010) I attended a meeting for cryonicists in their teens & twenties near Fort Lauderdale, Florida. The event was funded by Bill Faloon and the Life Extension Foundation. Cairn Idun, creator & coordinator of the Asset Preservation Group, created & coordinated this event as well. Although the Asset Preservation Group was created to devise means of protecting the assets of cryonicists during cryostasis, the group has expanded its concerns to many related issues, including nurturing future generations of cryonics activists to replace the current generation of aging cryonics activists.

The qualification for receiving a scholarship to attend the Teens & Twenties event was applying and being validated as having funding & contracts in place for cryopreservation with any cryonics organization, and being in the 12-30 age range. There were cryonicists from CI, Alcor, ACS, and KrioRus (the latter represented by Danila Medvedev). Some cryonicists were from Canada, Poland, Norway, the Netherlands and the United Kingdom. Altogether there were 33 cryonicists receiving scholarships, two spouses of those cryonicists who paid their own way plus 13 speakers and Members of the Asset Preservation Group (which includes me) —  for a total of 48 people attending at various times. Among the young cryonicists I believe there were only three teenagers: the two young sons of Bill Faloon, and 19-year-old CI/ACS Member Shannon Blevins,Jr.

By way of introduction, Bill Faloon described his experience of being a 19-year-old cryonicist attending the South Florida cryonics group in the 1970s. Wealthy cryonicists had sponsored him to attend a cryonics training and a life extension meeting in California. He believed that that sponsorship had paid big dividends for cryonics & life extension that he hoped would be comparable to the results of the LEF investment in this teens & twenties group for young cryonicists.

Everyone was then to give brief (under one minute) self-introductions. I won’t give many details, but there was a common theme of growing up with ideas & aspirations that were greatly different from those of friend & relatives. One young man is reputedly the only cryonicist in the state of Alabama. One young woman signed-up at the age of 16 and convinced her father to do so as well. She expressed a sentiment that many resonated with: “even individualists need a sense of community & belonging”. Before the meeting I had been concerned that many of those who had been signed-up for cryonics as young children by their parents would probably not be serious cryonicists. I was impressed by the extent of commitment to cryonics I saw among many of those who had been signed-up virtually from birth.

Although it is stereotypic that cryonicists are single, male computer nerds, 34% of these young cryonicists were female, and quite a few of them were involved with the entertainment industry. During the longer self-introductions Cairn noted five interest areas. The topics were: social networking, promoting cryonics through entertainment, cryonics-related science research, defending & promoting cryonics on the internet, and legal issues associated with cryonics. Cairn had the attendees separate into the five interest areas for discussion, and then we heard presentations from representatives of each group.

The next “getting to know you” exercise involved the participants classifying themselves by personality type as represented by the four colors green, blue, gold, and red:

Green — Conceptual, Curious, Wise, Versatile (intellectual, head rules heart)

Blue — Warm, Communicative, Compassionate, Feeling (seeks harmonious relationships)

Gold — Responsible, Dependable, Helpful, Sensible (dutiful, family-oriented, organization-oriented)

Red — Adventuresome, Skillful, Competitive, Spontaneous (seeks variety and physical involvement)

The participants were given colored sheets that described each personality color in detail as a means of assessing how much of each color composed their personality. Participants were to put various numbers of each color of dots on their name badges corresponding to how much each color is represented in their personality.

I later searched the internet for the basis of this classification system. I found some close matches, but nothing seemed exact:

http://en.wikipedia.org/wiki/Keirsey_Temperament_Sorter#Temperaments_and_intelligence_types

http://users.trytel.com/~jfalt/Ene-med/true-col.html

http://en.wikipedia.org/wiki/Myers-Briggs_Type_Indicator#The_four_dichotomies

Because most individuals are a mixture of all colors, we formed groups with others matching our dominant personality color. The largest group by far were the greens, followed by reds. There were only three blues and four golds. I felt that I had so much of all the colors that it was hard for me to choose. I finally decided that I had slightly more green and slightly less gold than the other colors. I joined the green group. Eliezer Yudkowsky regarded himself as so green that he covered his name badge with green dots. Cairn commented that greens generally predominate among cryonicists, and that she was glad to see so many of the other colors because all personality types are required for good teamwork.

On Saturday a presentation by futurist John Lobell was followed by more detailed self-introductions. I tried to tell the story of my life in five minutes. After the detailed self-introductions Catherine Baldwin gave a presentation about Suspended Animation,Inc. and Bill Faloon discussed future projects that young cryonicists should consider to further the advancement of cryonics. Bill was very concerned that there had been no dynamic spokesperson to defend Alcor against the Larry Johnson media blitz in October. Steve Valentine gave a presentation on the Timeship Project, a very expensive storage & research facility planned to store thousands of cryonics patients and transplantable organs at intermediate cryogenic temperatures (about minus 140 degrees Celsius). Although I have thought that the money lavished on this project could be better-spent in other ways, Bill Faloon is enthusiastic that Timeship will convince the world of the seriousness of human cryopreservation in a way that industrial park warehouses cannot.

Sunday morning there was a tour of Suspended Animation, Inc. followed by lunch at the SA facility. The tours were conducted in groups of ten, while the others socialized and watched digitized 40-year-old films (“Ice Men Cometh”) of Curtis Henderson & Saul Kent demonstrating human cryopreservation procedures & equipment during the early pioneering years of cryonics. After lunch there was a final “getting to know you” exercise where most of the participants moved from chair to chair having brief one-to-one conversations with most of the other participants. There were quite a number of people I had not had the chance to speak with earlier, and I found this exercise to be very helpful.

The rest of the afternoon was intended to be available for informal socializing at SA, but with people catching flights and the general restlessness it quickly became fragmented.

Overall I am very enthusiastic with how the weekend went. I made many valuable connections, as did most (if not all) of the others, I believe. It also lifted my spirits, which I also believe was a common experience. Bill Faloon wants to make this an annual event.

In the week after the Teens & Twenties event, I created a Facebook group “Young cryonicists”, and sent invitations to all of the attendee.

Early in the weekend I had asked Cairn to see who among the group did not want to be photographed. To my surprise, only one person did not. I took care not to include her in any of the pictures I took of the event. The following are a few of my photos:

Dinner at the Teens & Twenties event

Line-up for Steve Valentine to autograph Timeship posters

Danila Medvedev wears video/audio glasses that record his life
[Danila calls this Plan C for reconstruction of his personality if Plan A (life extension) and Plan B (cryonics) fail] (The glasses can record 10-12 hours of video with sound before the tape needs replacing. The batteries must be recharged at least every 5 hours.)

Participants watch pioneering cryonics films while others get tours of the Suspended Animation, Inc. facility

Young cryonicists Facebook page

A photo of some Teens & Twenties with Bill Faloon posted on Facebook by Bonnie Magee

A Facebook video of the Curtis Henderson “Ice Men Cometh” films

The 2009 SENS Conference

Once a year I try to attend at least one biogerontology conference. Although I attend biogerontology conferences out of personal interest, and at my own expense, they are the most fruitful grounds for promoting cryonics I have found, and this is especially true of SENS conferences.

I have missed none of the four SENS conferences that have been held at Cambridge University. “SENS” is Dr. Aubrey de Grey’s “Strategies for Engineered Negligible Senescence.”

SENS conferences attract scientists who are eager for science to achieve rejuvenation, and who have a strong belief that science has the capacity to do so. Not surprisingly, such people are often receptive to the idea that future science may be capable of reanimating humans who have been well cryopreserved.

Recently I have heard regret expressed about the aging of the cryonics community and the absence of a next generation of cryonics activists to replace the current ones. My experiences at the 2009 SENS conference dispelled much of my concern about this.

I took about a hundred CI brochures, but these were quickly taken by the 290 SENS conference attendees. I was continually approached by young scientists and researchers who were eager to meet me and who said they would make cryonics arrangements when they got out of graduate school and could afford to do so. Insofar as many of the attendees were Europeans, I was often asked whether the shipping delays to the United States would make cryonics not worth doing, and whether there were any plans by the Cryonics Institute to create a storage facility in Europe. (I was told about a group wanting to establish a storage facility in Switzerland, but I did not get any details. Apparently it is not a project with serious hope of success in the near future.)

I was astounded when a British student approached me and said that he would be devoting all of his graduate school work to the problem of cryoprotectant toxicity. He had already gotten Dr. Fahy to send him a copy of “Cryoprotectant toxicity neutralization,” a new paper to be published in an upcoming issue of CRYOBIOLOGY. The student is in the process of collecting other cryobiology publications that address the subject. I directed him to a relevant webpage in the cryonics section of my www.benbest.com website.

A number of people from KrioRus were at the conference, notably Igor Artyuhov, who is their technical guru. The group also does life extension research. Igor showed me their poster showing extended lifespan of mice administered heat-shock protein through nose-drops. I was interviewed by a journalist who writes for the Russian edition of SCIENTIFIC AMERICAN.

I had met Nick Mayer, a Terasem employee, at the previous SENS conference, and Nick introduced himself to me again at this meeting. Nick manages “cyberbiological systems”, specifically a website that is being used like an on-line personal diary. As Nick described it to me, the website would be useful to store personal information that could be used to help in the reconstruction of someone who has been reanimated from cryopreservation. But when I looked at his website, it appears to be a project for reconstructing people from their diaries alone — without any saved biological material.

To my surprise, one of the presenters, Dr. Gunther Kletetschka, had a poster and an oral presentation dealing with eliminating the cracking problem in cryonics.

Cracking of vitrified tissue at cryogenic temperatures is a consequence of the fact that external cooling causes superficial tissue to contract more than deep tissue (thermal conductivity is low). Dr. Kletetschka’s approach is based on the idea that if a cryonics patient were perfused with a solution containing gadolinium (nanoparticles would be best), an entire vitrified brain could be cooled uniformly by the magnetocaloric effect.

From a practical point of view, his sample size was apparently very small, and he did his testing on ice rather than vitrified tissue. I had many other criticisms of his approach, which I attempted to discuss with him in a constructive, supportive manner. He was interested in what I had to say, and was very receptive. Insofar as he is so enthusiastic about doing cryonics-related research, and insofar as he lives in Maryland (not so far from Michigan) I suggested that he attend the CI Annual General Meeting on Sunday, September 27. He expressed an interest in doing so.

A European student told me that his mother is a stroke victim, but that he has not been able to induce her to consider cryonics. Having experienced the debilitating effects of stroke she is worried that faulty reanimation procedures would bring her back into an even more debilitated condition. I suggested asking her to assess the probability of that happening and how bad the downside would matter if the probability is small. I think that in the context of all of the other repairs that would be essential to cryonics working that it is unlikely that all such defects would not be fixed.

A middle-aged European woman wanted to speak with me about how to convince her husband that cryonics is a good idea. The couple are both religious, but she thinks “heaven can wait” because she enjoys life here on earth and she would like to share earthly life for a very long time with her husband. I gave her many arguments against the claim that cryonics is against religion, including the one concerning refusing a lifesaving medical treatment being equivalent to suicide (a sin).

I was reminded of the Depressed Metabolism posting about the “hostile wife phenomenon” in cryonics:  It occurs to me that when a male spouse is interested in cryonics, but his wife is not, that he can go ahead and make the arrangements. A financially dependent woman (as this woman is), less often has that option. I have also often seen cases of women interested in cryonics, but who dropped the interest when it became clear that their spouse would not join them in cryostasis. They would rather not live if they cannot be with their husbands. It reminds me of studies of working couples that show that a wife is much more likely to quit her job to follow her husband in a career change that involves moving — whereas the opposite happens much less frequently.

I won’t say much about the SENS conference itself, but I had lots of meetings and discussions that taught me a lot about biogerontology issues. I was particularly interested in discussing my recent article “Nuclear DNA Damage as a Direct Cause of Aging” which had been published in Rejuvenation Research, because it is a direct challenge to one of the tenets of SENS (that nuclear DNA damage only matters for cancer).

Not only was I able to have two private sessions in which I discussed the matter with Aubrey de Grey, but I was able to eat breakfast several times with Vera Gorbunova and her husband Andrei Seluanov, two DNA repair experts who were attending the conference. Vera and Andrei have written the only other review (other than my own) supporting the thesis that nuclear DNA repair capability declines with age.

I had cited that review in my own review. Vera had sat across from me at my first breakfast by chance. She had read my review and told me that she agreed with it. Most of the times that I went for a meal I was very pleased by at least one person randomly sitting near me, and had an interesting and productive discussion with them on a matter of interest. I discussed my cryonics alarm system problems with a woman who is getting a PhD in biomedical engineering.

I was very surprised and pleased to meet Kristen Fortney at the conference. Kristen is a University of Toronto student who attended some of our cryonics meetings in Toronto. She was a physics student and was planning to do graduate work in quantum physics. At the conference she told me she had changed to a PhD program focused on computational work with the human genome, focused on anti-aging strategies. She wrote a blog of the conference as it progressed on the Ouroboros academic blog for aging research.

"Scientific Justification of Cryonics Practice" in Russian

Danila Medvedev has translated Ben Best’s  article “Scientific Justification of Cryonics Practice” into Russian. The translation is available on the KrioRus website. The original Engish article was published in Rejuvenation Research and is available as a PDF file at the Cryonics Institute website.

ABSTRACT

Very low temperatures create conditions that can preserve tissue for centuries, possibly including the neurological basis of the human mind. Through a process called vitrification, brain tissue can be cooled to cryogenic temperatures without ice formation. Damage associated with this process is theoretically reversible in the same sense that rejuvenation is theoretically possible by specific foreseeable technology. Injury to the brain due to stopped blood flow is now known to result from a complex series of processes that take much longer to run to completion than the 6 min limit of ordinary resuscitation technology. Reperfusion beyond the 6 min limit primarily damages blood vessels rather than brain tissue. Apoptosis of neurons takes many hours. This creates a window of opportunity between legal death and irretrievable loss of life for human and animal subjects for cryopreservation with possibility of future resuscitation. Under ideal conditions, the time interval between onset of clinical death and beginning of cryonics procedures can be reduced to less than 1 min, but much longer delays could also be compatible with ultimate survival. Although the evidence that cryonics may work is indirect, the application of indirect evidence is essential in many areas of science. If complex changes due to aging are reversible at some future date, then similarly complex changes due to stopped blood flow and cryopreservation may also be reversible, with life-saving results for anyone with medical needs that exceed current capabilities.